DOCK8 regulates signal transduction events to control immunity

DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

DOCK8 mutations result in an inherited combined immunodeficiency characterized by increased susceptibility to skin and other infections. We show that when DOCK8-deficient T and NK cells migrate through confined spaces, they develop cell shape and nuclear deformation abnormalities that do not impair chemotaxis but contribute to a distinct form of catastrophic cell death we term cytothripsis. Suc...

DOCK8 regulates protective immunity by controlling the function and survival of RORγt+ ILCs

Retinoic acid receptor-related orphan receptor-γt-positive (RORγt(+)) innate lymphoid cells (ILCs) produce interleukin (IL)-22 and IL-17, which are critical for protective immunity against enteric pathogens. The molecular mechanism underlying the development and survival of RORγt(+) ILCs is not thoroughly understood. Here, we show that Dedicator of cytokinesis 8 (DOCK8), a scaffolding protein i...

MyD88: a critical adaptor protein in innate immunity signal transduction.

Control Design for Signal Transduction Networks

Signal transduction networks of biological systems are highly complex. How to mathematically describe a signal transduction network by systematic approaches to further develop an appropriate and effective control strategy is attractive to control engineers. In this paper, the synergism and saturation system (S-systems) representations are used to describe signal transduction networks and a cont...

Signal transduction events in chicken interleukin-1 production.

The HD11 chicken macrophage cell line was studied for growth characteristics using different culture media, serum concentrations, and incubation temperatures. Growth curves at 37 C revealed that the cells grew best in RPMI 1640 medium supplemented with 10% colostrum-free bovine serum (CFBS). Growth was not supported by RPMI 1640 medium supplemented with the serum replacement Nu Serum nor by PC-...